Overwhelming support from the Rapa Nui to create an MPA around Easter Island

On the first day of IMPAC4 in La Serena, Chile’s Ministers for the Environment, Marcelo Mena, and Minister of Foreign Affairs, Heraldo Muñoz, announced the results of a referendum held Sunday, 3rd September 2017 on Easter Island for the creation of a marine protected area. The vote, which had the largest turnout for a consultation ever held on the island, resulted in 73% approval for the creation of an MPA that would protect the island’s exclusive economic zone from industrial commercial fishing, mining and other extractive activities while grandfathering in Rapa Nui artisanal fishing.

The Pew Bertarelli Ocean Legacy Project issued the following statement in response to the vote.

Dona Bertarelli, co-chair of the Bertarelli Foundation said:

“I am delighted that the referendum has given such strong endorsement for the creation of an MPA around Easter Island. This demonstrates the value of working with local communities to achieve the best outcome to protect both their livelihoods and the oceans for generations to come.”

Matt Rand, director of the Pew Bertarelli Ocean Legacy Project said:

“This is a historic moment for the conservation of the world’s ocean, and the protection of the Rapa Nui environment and culture. We are thrilled that, after working with the community for over five years, the Rapa Nui have voted in support of a marine protected area. We are hopeful that President Bachelet will codify the Rapa Nui proposal.

There has been an extensive vetting process with the Rapa Nui and the final decision by the community is to support a marine protected area. This is the important step to hopefully realize the community’s vision to protect their ocean and culture. We have been privileged to have worked so closely with the Rapa Nui on this endeavor over the last five years. The power of this partnership between committed indigenous local people and our outside expertise has been remarkable.

The Rapa Nui have chosen conservation of the environment, their culture and their traditions over commercial exploitation. This should be commended. It’s not often that communities choose conservation over exploitation. Hopefully this sets the course for the rest of our world.”

A conversation with Giffin Daughtridge, winner of the 2017 Bertarelli Prize

Giffin Daughtridge, MD is the co-founder and CEO of UrSure, a venture he started with Dr. Helen Koenig at Harvard University’s Innovation Lab, and winner of the 2017 Bertarelli Prize.  Giffin kindly made time to let us know how the iLab and the Bertarelli Prize have helped him achieve his goal of reducing the spread of HIV.

How is UrSure tackling the spread of HIV?

We’re developing tests that let doctors monitor whether their patients are adhering to their PrEP (Pre-Exposure Prophylaxis) regimens. Whilst PrEP only requires a single oral dose per day to be 99% effective at preventing HIV, studies have shown that over the course of a year, adherence to even simple drug regimens can fall to as low as 20 to 50%.  Until recently the only way for clinicians to determine adherence of their patients to PrEP was through self-reporting – a notoriously un-reliable method.

Why is it important to know whether patients are taking their PrEP Medication?

Missing doses can seriously reduce the protection provided to the patient and could lead them to contract HIV.  It’s important for clinicians – and patients – to know that they are protected from infection.

UrSure is developing two tests which will give clinicians an accurate assessment of their patients’ adherence.  The first is a lab-based urine test which provides a quantitative indication of the level of PrEP medication in the patient’s system.  Whilst this is an important tool, it does not give an immediate result.  It also requires the patient to meet with their clinician on another occasion to discuss their test results.  For some patients with chaotic or busy lifestyles, this is a huge hurdle.

We were keen therefore to develop a cheaper test which gives an immediate, albeit binary, result.  We are developing a ‘point-of-care’ urine dip-test, similar to a pregnancy test, which tells clinicians whether their patient is taking their medication.

How did you realise there was need to develop this new test?

I graduated from the University of North Carolina at Chapel Hill in 2011 and went to Colombia on a Fulbright research scholarship. While there, I started a vaccination clinic for sex workers.  After a year I moved back to the US and met Dr. Helen Koenig, an infectious disease physician, who was starting a PrEP clinic in Philadelphia, PA.  In our clinic, we realised very quickly that we didn’t know with any confidence whether our patients were taking their medication – in fact, one of our patients contracted HIV, something which would not have happened if he were taking his medication as prescribed.

Helen and I started to think about how this test might be administered.  We didn’t want to develop another blood test for this group of patients and instead decided to see if a patient-friendly urine test might be the way forward.

In 2015 we incorporated UrSure Inc. in order to allow us to apply for a Small Business Innovation Research grant and to other funding streams.  I quickly realised that in order for UrSure to be a success I couldn’t run the company and complete my residency – so I decided to work on UrSure on a full-time basis after graduating medical and policy school.

How has winning the Bertarelli Prize helped UrSure develop?

For Helen and I it has been a game-changer by helping us accelerate the development of our products.  The prize of $75,000 USD, along with other prizes and funding we’ve been able to secure since, will help us develop our point-of-care test and overcome legal and regulatory hurdles that exist to new products entering the marketplace.

But the iLab Challenge is about more than just the prize fund.  Harvard’s iLab provides an incredible place to learn and develop a complete business plan.  When I started in October 2015, I had no idea how to start a company, I knew nothing about business, how to scale-up or how to create a financial model – but the great thing is, the iLab has plenty of people who do.  I sincerely believe that UrSure wouldn’t be where it is today if it weren’t for the entire iLab ecosystem – the facilities, the Challenge and the Bertarelli Prize.

What’s next for UrSure?

Now that our clinical test has been validated, we’re working with commercial laboratories to have doctors, patients and insurance companies start using the test.  Ultimately, we want to scale up so we are providing tests for as many PrEP patients as possible – there are over 100,000 in the US alone.

We’re continuing to develop our Point of Care urine test and we hope to have that ready for our clinical trials by 2018.

More incredible data is collected from the Chagos Archipelago

In late April and early May, Dr David Jacoby of the Zoological Society of London and Dr Taylor Chapple of Stanford University spent a week at sea attempting to retrieve data from deep-sea receivers scattered across the marine reserve in the British Indian Ocean Territory. The receivers pick up signals from pelagic animals that the team tagged on previous trips including sharks, rays and tuna – the big predators that are hard to study but absolutely key to a healthy ecosystem.  These 16 receivers were deployed in 2016 in a variety of deep-water habitats such as sea mounts and undersea canyons, places too deep for divers and until now virtually unstudied by scientists.

In just six days, with the help of the crew of the British Patrol Vessel Grampian Frontier, the team traversed the Chagos Archipelago from end to end travelling over 500 miles. They managed to retrieve 12 of the 16 receivers by using an automated acoustic release system which ‘calls’ the receiver from the surface causing it to break free of its mooring and float up to be collected by the team.

Early analysis of the data from the receivers has revealed an incredible wealth of information; over 500,000 individual detections were downloaded – each one an individual pass of a tagged animal past one of the receivers. Receivers located at the Schwartz and Sandes seamounts in the south of the archipelago made detections of 159 unique individuals and are starting to reveal some of the connectivity between these deep habitats.

Dr David Jacoby and Dr Taylor Chapple service and replace the battery in a VR4 acoustic receiver, just south of Peros Banhos in the Chagos Archipelago, so that it will continue transmitting live data for another year.

Additionally, an Acoustic Doppler Current Profiler, retrieved from ‘Manta Alley’ at Egmont Island has collected information about the current profiles of this newly discovered manta highway and will provide vital environmental data for assessing why this area if so important for this iconic species.

Though short, this trip was very successful and will reveal more of the habitats and movements of these amazing species around this huge marine protected area. The acoustic receiver array, funded by the Bertarelli Foundation, is contributing to a long-term data set that is unparalleled in its size and geographic coverage and continues to grow by the day. All the data are now on their way back to the lab at Stanford University for in-depth analysis.

UrSure Inc. win the 2017 Bertarelli Prize at Harvard University’s iLab

For the last several years, the Bertarelli Foundation has proudly sponsored Harvard University’s Innovation Lab.  More specifically, we have provided the Bertarelli Prize, which is awarded to the winner of the ‘Health & Life Science Track’ in the annual President’s Innovation Challenge.

The Innovation Challenge supports Harvard students on their journey to turn their desire for a better world into a sustainable venture. This year’s finalists responded to the desperate need for innovation within the health and life sciences industry, as well as solve social issues (equitability, sustainability and safety), and also innovate in other areas that transcend the Challenge categories.

This year, more than 200 student teams applied to participate in the Innovation Challenge with the finalists being selected by a committee of more than 150 judges with a wide array of industry experiences.

In March, five finalists were selected for the 2017 Bertarelli Prize:

  • Day Zero Diagnostics combines genome sequencing and machine learning to modernise infectious disease diagnosis.
  • GEMS Samaritan Stations has developed a smart devices that reduces emergency response time by turning bystanders into first responders when every second counts.
  • Jane Diagnostics has produced an innovative, low-cost, accurate, rapid, and easy-to-use HPV diagnostic chip for early detection of cervical cancer.
  • Nanoshear has created a nanotechnology-based liquid embolic agent for immediate haemorrhage control in vascular injuries and bleeding patients.
  • UrSure Inc. prevents HIV by focusing on protecting vulnerable populations from infection.

Given the exceptional quality of all the finalists, it was a very difficult decision for the prize judges to select the winners; ultimately however, UrSure Inc. was awarded the Bertarelli Prize of $75,000 and Jane Diagnostics were awarded the runner-up prize of $25,000.

The team behind UrSure are no strangers to the Bertarelli Prize, having participated in the competition in 2016.  In the year which followed, Giffin Daughtridge and Helen Koenig were able to refine both their product and their business plan and ultimately impress the prize judges.

Ernesto Bertarelli commented:

I’d like to congratulate all the finalists and entrants for the Bertarelli Prize.  I’m confident that by taking part in the Challenge over the last year, you will have refined your business ideas and embraced the entrepreneurial spirit which is so important if you are to succeed in your ambition.

I’m delighted that Giffin and Helen of UrSure Inc. have been able to develop such an important medical tool which shows great promise in helping to reduce HIV infection.  I will watch the development of their company very carefully.

UrSure’s CEO and founder Giffin Daughtridge, commented:

Winning the Bertarelli Prize is an absolute game-changer for us.  We had enough funding to get through the next couple of months, but this will help us accelerate our timeline.

 

Expedition to survey corals in the British Indian Ocean Territory

The Bertarelli Foundation recently supported an expedition to British Indian Ocean Territory, one objective of which was to survey damage to the coral reef from previous bleaching events, and to see the extent of any damage this year.  Dominic Andradi-Brown of the University of Oxford provided this update.

I’ve just returned from two weeks of coral reef surveys in the Chagos Archipelago. While logistically and scientifically the expedition was a great success, the coral reef health surveys we conducted suggested there has been widespread coral death here over the past couple of years.

Last year, during the April expedition, we recorded a coral die off in the shallows, particularly with the large plating and branching Acropora corals dying off that previously dominated these reefs.

The reefs were characterised in the shallows by many large upturned plates, with the few Acropora colonies still alive but looking heavily diseased.

Many of the other branching corals, such as Pocillopora, were still alive but showing signs of bleaching.

Bleaching, which is caused by high sea temperatures combined with sunlight exposure for a prolonged period of time, doesn’t necessarily kill corals. There are plenty of examples of corals recovering following bleaching events, and in fact these corals that do recover are the focus of research as they may hold the key to coral reef survival through climate change.

The positives from our 2016 trip were there were lots of healthy young corals, called recruits, that had settled onto the reef, offering hope that the reefs of the archipelago could recover.

We left the 2016 expedition slightly apprehensive about what would happen to the reefs next. Would the dead Acropora plates erode down destroying many of the coral recruits? Would the Pocillopora recover following the bleaching?

So it was with much trepidation we returned this year to see what further changes there had been. At first glance the shallow reefs looked fairly similar, after all, the plating Acropora that had previously died off had been the dominant coral at many sites.

Dead Acropora corals being surveyed after this year’s bleaching event

However, as we got further into surveys we began to notice that the many other branching corals, such as the Pocillopora, that were bleaching as we left last year had now died as well.

In several places we encountered large rubble patches, most likely caused from the erosion and breakdown of the branching corals that had died over the previous two years.

Unfortunately for the reefs of the Chagos Archipelago it seems they have had two years of back-to-back change.

Rubble patch from broken down branching corals

Despite this there are a few glimmers of hope.

Generally the deeper reefs below 20 m depth appeared reasonably healthy, with high coral cover. In the shallows, the remaining living corals (mostly Porites species) seem in good condition and there was no sign of further bleaching in progress while we were there.

Healthy Porites corals in shallower waters

Many of the coral recruits we observed last year have survived and grown. As part of our survey work this year we were interested in tracking reef recovery. So we have identified individual young Acropora colonies, measured their surface area and 3D structure to be able to track their growth over the next few years.

Young Acropora corals will be measured over the next few years to record their growth and recovery

There is hope that the reefs of the Chagos Archipelago can recover, as a similar coral die-off happened back in 1998 from which the reefs recovered.

However, the key question is the frequency with which bleaching occurs, and whether there will be time for recovery before the next big bleaching event.

Thanks to the Bertarelli Foundation for funding the expedition. For updates from when we were in the field, please search for the hashtag #BIOTExp17 on twitter.

 

New Conservation Posts on Turneffe Atoll help enforce the marine reserve

On the 1st March 2017, the Turneffe Atoll Sustainability Association (TASA) opened two new buildings on the atoll to increase the effectiveness of their enforcement and education activities.

The Turneffe Atoll Marine Reserve, which is co-managed by TASA along with the Government of Belize, was established by law in 2012 and is both the largest marine reserve in Belize, and the largest atoll in the northern-hemisphere. The area is of crucial importance for local and commercial fishing, as well as lobster and conch diving.

TASA’s main station, which houses five permanent rangers is housed on Calabash Caye, while its secondary outpost which houses four rangers is on Mauger Caye to the north of the atoll.

Fisheries Administrator Beverly Wade, and Jose Alpuche, Chief Executive Officer in the Ministry of Agriculture, Forestry, Fisheries, the Environment, Sustainable Development, and Immigration did the official ribbon cutting  and were joined by many others with a keen interest in seeing the marine reserve succeed.

The new buildings were  funded by the Bertarelli Foundation, as part of our ongoing commitment to help Turneffe Atoll recover from decades of misuse and over-fishing.

Valdemar Andradi, TASA’s Executive Director, explained why the new conservation posts will help their work:

Our role is to monitor Turneffe Atoll to ensure that those using the area comply with fisheries regulations and sustainable management of the area’s resources.

Our new presence on two sites will allow for more daily patrols when rangers will be able to monitor for illegal fishing, unlicensed development, as well as to ensure compliance with development permits.

Mauger Caye rangers will patrol from the north to the central atoll, and Calabash Caye rangers will patrol from central to south.

 

 

Pitcairn Islands’ Marine Reserve declared at Our Ocean

At the third Our Ocean conference, held on Thursday, 15th September in Washington DC, the British Government declared the waters around the Pitcairn Islands as a complete, no-take marine reserve covering 834,334 km2. This is an incredible step forward for the health of the planet – protecting large expanses of ocean helps to protect entire marine ecosystems and maintain biodiversity in the seas on which all life on earth depends.

The Pitcairn Islands are a group of four remote islands – Pitcairn, Ducie, Oeno, and Henderson – in the middle of the Pacific Ocean. Though the islands are themselves small, the territory has one of the largest Exclusive Economic Zones in the world, within which lies some of the most important oceanic ecosystems.

Famous as the island inhabited by descendants of the mutineers from the HMS Bounty, the waters around Pitcairn contain some of the best coral reefs in the world and intact deep-sea habitats with many species new to science. Mindful of the treasures that lie around their home, the Pitcairn islanders called for the creation of a Marine Protected Area. Accordingly, in March 2015, the British government announced their intention to ban commercial fishing and designate the territory as a marine reserve as well as to create a ‘Blue Belt’ around other British Overseas Territories.

Following that announcement, the Bertarelli Foundation, together with the Pew Charitable Trusts, supported the trailing of new technologies such as the UK Satellite Applications Catapult’s ‘Eyes on the Sea‘ and Liquid Robotics Waveglider platform.  This trial helped to inform the creation of an effective monitoring and enforcement strategy, and paved the way for the final designation of the reserve.

Sir Alan Duncan, Minister of State at the UK Foreign Office announced the final designation of the reserve at the 2016 Our Ocean conference and added:

“Protecting four million square kilometres of ocean is a fantastic achievement, converting our historic legacy into modern environmental success. This demonstrates our commitment to delivering the Blue Belt pledge.”

On hearing the news, Ernesto Bertarelli commented:

“I’m delighted to continue our successful partnership with the UK government.  This significant designation will help protect an important part of the ocean using the next generation of monitoring and enforcement technologies.  It is my hope that other governments will look at what we’ve supported around Pitcairn when considering how they might monitor and enforce their own marine reserves.”

The Bertarelli Foundation announces a new partnership to protect even more of the ocean

For the last seven years, since it began its major support for what was then the world’s largest marine protected area around the British Indian Ocean Territory, encompassing both enforcement and scientific investigation, the Bertarelli Foundation has worked across the globe helping governments and local communities create marine reserves. On Wednesday, 14th September, Dona Bertarelli announced the Foundation’s latest partnership which will safeguard some of the most vulnerable parts of our ocean.

At the third Our Ocean conference in Washington DC, Dona Bertarelli announced the creation of the Pew Bertarelli Ocean Legacy Project, a new partnership to conserve the world’s oceans and create the next generation of parks in the sea:

“Sailing competitively around the world I have seen first-hand the devastation that man’s influence is having on our oceans – whether through over fishing, plastic pollution or acidification.  The need to create large marine reserves could not be greater than it is today, and I’m very proud that the Bertarelli Foundation is building on its work in this area, now in partnership with Pew, to create more of these vitally important sanctuaries which will help protect not just the ocean but the way of life of those who depend on it.”

The $30 million partnership builds upon an existing collaboration which has seen both organisations work to protect huge areas of ocean in the Pacific Ocean, around the neighbouring Pitcairn Islands and Easter Island. This represents almost four years of working with local communities, governments, scientists, and other stakeholders to advance the cause of these incredible places.

In 2013 the Bertarelli Foundation partnered with Pew to support satellite monitoring to detect illegal fishing activity in the waters around Easter Island, Chile, helping to provide evidence that fish were being caught illegally and to support the case for a marine reserve. In the UK the Bertarelli Foundation and Pew have worked together to provide  monitoring of fishing activity in the waters surrounding Pitcairn  in support of the British Government’s efforts to finalise the designation of the Pitcairn Marine Reserve.

More ocean has been set aside for protection in the past 18 months than during any other period in history, with announcements of new marine reserves by the governments of the U.S., the United Kingdom, New Zealand, Chile, and Palau. But even with these successes, only about 3 per cent of the world’s ocean has been set aside with strong protections.

By harnessing the recent global momentum and political courage of world leaders who have taken action to conserve our ocean, the Bertarelli Foundation and the Pew Charitable Trusts’ partnership will scale up efforts to secure a future of healthy oceans that was once unimaginable.

Aldatu Biosciences is helping to overcome HIV drug resistance

After winning the Bertarelli Prize in 2014, Aldatu Biosciences has continued developing their PANDAA technology which aims to improve HIV patient care by detecting antiretroviral drug resistance.  Since then, others have also recognised Aldatu’s potential and they were awarded the Verizon Powerful Answers Award and in 2015 awarded a Direct-to-Phase II Small Business Innovation Research grant for approximately $1,500,000 over two years.

Co-founders, David Raiser and Iain MacLeod, travelled to Botswana to meet researchers at the Harvard AIDS Institute.  We went with them to find out how the Bertarelli Prize helped their businesses grow and how their technology might help HIV patients ensure they are receiving the correct treatment.

Herald win the 2016 Bertarelli Prize at Harvard’s iLab

Each year, the Harvard i-lab holds the Deans’ Health & Life Sciences Challenge to encourage cross-disciplinary innovation and to solve some of the world’s toughest health problems.

The year’s five finalists were selected to present their business ideas at the i-lab Demo Day on Wednesday, 4th May, and compete in the final stage of the competition for the Bertarelli Prize.

Herald, whose healthcare software offers clinicians real-time access to clinical data, won the Bertarelli prize of $30,000 and the chance to incubate their idea in the Harvard i-lab through the summer. The company’s chief executive, Brad Diephuis, is an MD/MBA candidate, a dual degree that prepares graduates for a career in healthcare management and finance.

Pykus Therapeutics, a new company which makes a dissolvable device that doctors inject into a patient’s eye to make retinal surgery less painful, was selected as the Challenge’s first-runner up. They received $25,000 prize and summertime access to the i-lab incubator.

LuminOva takes great strides tackling infertility

In 2015, LuminOva, a biotech start-up company based in Boston MA., won the Bertarelli Prize at Harvard University’s iLab.  The prize is awarded annually as part of the Deans’ Health and Life Sciences Challenge which encourages nascent businesses to develop and grow towards commercialisation.

Whilst many businesses enter the Challenge each year and benefit from the mentoring, workshops and judging process, only one can win the Bertarelli Prize.  Providing a welcome stamp approval, the Prize also comes with a substantial financial award which catapults the businesses forward and helps them to overcome barriers and hurdles to their success.

LuminOva is developing a new technology which could help infertile couples select the best embryos for IVF treatment.  Whilst still undergoing clinical trials, winning the Bertarelli Prize has accelerated  the development of the company and will hopefully bring their product to market more quickly – and in so doing, help people achieve their dream of becoming parents.

The ABNJ PrepCom concludes its first meeting in New York

A landmark resolution was adopted, in June 2015 by a consensus of UN member states, to develop a legally-binding treaty for the conservation of marine life beyond national territorial waters – that area of the ocean shared by all. Resolution UNGA 99/292 signalled a major step forward toward convening an intergovernmental negotiating conference that would finalise the terms of the new treaty, possibly in 2018. The resolution called for a two-year process which began last week at the UN Headquarters in New York; Dona Bertarelli attended the meeting on behalf of the Bertarelli Foundation and left New York feeling positive about the future:

The sea is in the blood of my brother and I. We’ve sailed since we were children, first in Italy with our parents, and then as we’ve grown older, we have both competed, raced yachts and broken records.  Our love of the sea has spread to our own children; it’s because of the next generation, and those that will follow, that we care so passionately about the health of the oceans, and are determined to play our part in protecting them.

The Bertarelli Foundation is proud to have been at the centre of efforts to create Marine Protected Areas. But we know that these can only ever cover a tiny proportion of the world’s oceans. That’s why the United Nations initiative to protect the high seas is so important.  Ultimately, the aim is to have a treaty that will include capacity-building, technology transfer, and crucially, good governance.  It will need to consider fisheries and marine genetic resources, as well as the fast-developing technologies that enable deep-sea mining.

The first formal step towards creating that treaty came last week, with the initial Preparatory Committee meeting (PrepCom) at the UN HQ in New York. I was privileged to attend on behalf of the Bertarelli Foundation and meet the key players attempting to bring about a robust and ambitious accord.  The Chair of the PrepCom, Ambassador Eden Charles, told me how important it is for there to be a strong agreement – and is acutely aware of the challenges of getting all member states to agree. But he was encouraged by the commitment and enthusiasm being shown in the meeting room: as I sat in the session it was good to hear that every country recognised the importance of the health of the seas, including landlocked states such as our home nation of Switzerland.

Ambassador Charles highlighted the efforts made by civil society even to get to this stage, and so I was delighted that the Bertarelli Foundation could bring together representatives of the lobby groups and nation states, to enable informal conversations and an opportunity to discuss what is at stake.

There is no doubt that a huge amount of work lies ahead. It will take years to reach a final agreement and iron out the details.  As Lisa Speer from the National Resources Defence Council pointed out to me, though, this is about figuring out the future of half the planet.  Like sailors battling for the finish line, what’s needed now is determination and tenacity: and I saw plenty of that in New York.

Dona Bertarelli